Questionnaire for data collection
Person in charge of human xenotransplantation practice.
Title : Professor.
First Name: Patrick
Last name : Aebischer
Address :
Zip :
State : Lausanne
Country : Switzerland
Institution : Gene Therapy Center and Division of Surgical Research, CHUV
Telephone :
Email :
What is the source of your information about human xenotransplantation practices?
Publication
What is the therapeutic purpose of this xenotransplantation treatment?
amyotrophic lateral sclerosis
Where and when is this human xenotransplantation practice taking place?
Country Switzerland
Timing In 2000
Is this treatment part of a clinical trial?
Yes
How many patients are included in this clinical trial?
12
What are the inclusion criteria for patient selection?
i. Duration on the waiting list? unknown
ii. Life-threatening diseases without alternative therapy? Yes
iii. Is a protocol available? Yes
If yes, could you please send a copy?
What is the animal source of the xenotransplantation product?
Hamster
Source animals Do you have information about source animals? No
Testing of safety : Do you have information about testing of safety? No
What type of cells/tissues/organs was transplanted?
Cells:
Tissues:
Organs:
Others:
Kidney cells
What type of exposure to xenogeneic cells was involved?
Solid-organ xenotransplantation: No
Cellular xenotransplantation: Yes
Tissue xenotransplantation: No
Human cells exposed to xenogeneic Feeder cell: No
Extracorporeal perfusion: No
Encapsulation: Yes
Other bioartificial isolation device:
Others:
Transplant Do you have information about transplant recipients? No
Have results been presented at a scientific congress?
Unknown
if yes, where?
Have results been published in a scientific journal?
Yes
if yes, where?
Zurn AD et al.,Evaluation of an intrathecal immune response in amyotrophic lateral sclerosis patients implanted with encapsulated genetically engineered xenogeneic cells.Cell Transplant 2000 Jul-Aug;9(4):471-84
Is this human clinical trial performed with governmental and/or institutional oversight and supervision?
Unknown
if yes, which?
Comment

They used genetically engineered baby hamster kidney (BHK) cells releasing human ciliary neurotrophic factor